Principles of Pharmacology with Research Methods

Kingston University

Course Description

  • Course Name

    Principles of Pharmacology with Research Methods

  • Host University

    Kingston University

  • Location

    London, England

  • Area of Study

    Biology, Biomedical Sciences, Life Sciences, Research

  • Language Level

    Taught In English

  • Prerequisites

    ? For Study Option 1 and 2, successful completion of level 4 introductory study of
    life sciences.
    ? For Study Option 3, previous experience of pharmacology and aspects of drug
    disposition relating to drug absorption/distribution.

  • Course Level Recommendations

    Upper

    ISA offers course level recommendations in an effort to facilitate the determination of course levels by credential evaluators.We advice each institution to have their own credentials evaluator make the final decision regrading course levels.

    Hours & Credits

  • Credits

    4
  • Recommended U.S. Semester Credits
    4
  • Recommended U.S. Quarter Units
    0
  • Overview

    Course Content:

    Research methods and employability skills are taught within the context of
    pharmacological research and associated industries. Students are introduced to the
    basic concepts of pharmacodynamics (how drugs take their effect at given targets) and
    drug disposition/pharmacokinetics (the effect the body has on administered drugs),
    whilst considering the factors which influence such parameters and thus lead to
    individual variability in drug response.

    The module goes on to discuss the principles of toxicology, how drugs are discovered and
    developed, and the role of pharmaceutical sector / regulatory bodies in this process.

    Autumn Semester summary: Pharmacolodynamics, Drug disposition (absorption,
    distribution) Pharmacokinetics; research skills & statistics.

    Topics covered may include:
    ? Research Methods: further statistics, experimental design & SPSS; use of
    research literature; scientific communication and presentation; ethical issues
    ? Employment skills: career options; investigation of business industry; selfreflection;
    teamwork/project management
    ? Introductory Pharmacology:
    Pharmacodynamics: Basic pharmacological definitions; Targets for drug action;
    Pharmacological definition of receptors and receptor superfamilies; Drugs acting
    at receptors both as agonists (full and partial) and antagonists (competitive and
    noncompetitive); Concept of the dose-response relationship. Phenomena of
    tachyphylaxis and desensitisation to drugs.

    Spring Semester summary: drug disposition (metabolism, excretion) Pharmacokinetics,
    Drug Development & Clinical Trials, Toxicology.
    ? Introduction to the concept of toxicology: Mechanistic targets of toxicant
    action; Measurement of toxicological parameters.
    ? Drug / toxicant disposition and kinetics: Routes of administration of drugs;
    Mechanisms of, and factors influencing, drug / toxicant absorption,
    distribution, metabolism and excretion;
    Pharmacokinetics: One compartment models; concept of volume of
    distribution, half-life, elimination, clearance and steady state. Differences
    between intravenous and oral dosing.
    ? Individual variability in drug and toxicant response: Classification of
    response variability (dynamic or kinetic); Effect of age, environment, diet,
    disease, genomics and differing physiological states on the response to drugs
    and toxicants; Adverse drug reactions.
    ? Drug development and clinical trials: Overview of the pharmaceutical
    industry; Drug design and identification of a target site; Animal usage and the
    law; Preliminary drug screening using in vitro and in vivo models; Concept of
    risk assessment and preclinical safety testing including the validity of using
    animal data; Clinical trials; phase I - IV trials, trial design and the information
    gained at each phase; The role of the ethics committee in the clinical trial
    process and the relevant regulatory bodies in product licensing and postmarket
    monitoring.

    Teaching: Lectures, seminars, workshops and laboratory practical sessions

    Assessment:
    STUDY OPTION 1:
    ? Exam (50%)
    ? Practical: Group oral presentation (20%)
    ? Coursework: Critical review (30%)
    STUDY OPTION 2:
    ? 2 practicals & group oral presentation
    STUDY OPTION 3:
    ? 1 practical
    ? modified examination

    Study Option 1 = Whole Year
    Study Option 2 = Autumn
    Study Option 3 = Spring/summer

Course Disclaimer

Courses and course hours of instruction are subject to change.

Eligibility for courses may be subject to a placement exam and/or pre-requisites.

Some courses may require additional fees.

Credits earned vary according to the policies of the students' home institutions. According to ISA policy and possible visa requirements, students must maintain full-time enrollment status, as determined by their home institutions, for the duration of the program.

Please reference fall and spring course lists as not all courses are taught during both semesters.

Please note that some courses with locals have recommended prerequisite courses. It is the student's responsibility to consult any recommended prerequisites prior to enrolling in their course.