Proteins and Metabolism
Area of Study
Botany, Life Sciences, Molecular Biology
Taught In English
Successful completion of introductory university-level module such as LS4002 or similar
Course Level Recommendations
ISA offers course level recommendations in an effort to facilitate the determination of course levels by credential evaluators.We advice each institution to have their own credentials evaluator make the final decision regrading course levels.
Recommended U.S. Semester Credits4
Recommended U.S. Quarter Units0
Hours & Credits
The module provides students with knowledge of the structure and methods of analysis of
proteins, with particular emphasis on enzymes. This is followed by the study of the major
catabolic and anabolic pathways and investigates how organisms obtain and use energy.
These processes, and their regulation in health and disease, are considered at the
molecular level, which involves many proteins including enzymes.
Autumn Semester sumamry: the structure and methods of analysis of proteins, with
particular emphasis on enzymes. Brief introduction of Bioenergetics.
Spring Semester summary: the study of the major catabolic and anabolic pathways and
how organisms obtain and use energy. Regulation of these in health and disease, are
considered at the molecular level, which involves many proteins including enzymes.
Topics covered may include:
? Amino Acids - Revision of basic structure and chemical properties. Structure of
? Protein Structure - Structure and properties of the peptide bond, levels of
protein structure relating to primary structure and function of proteins.
? Enzymes - Structural features of enzymes relating to function. Measurement of
enzyme activity, including calculation of kinetic parameters and enzyme
? Spectroscopy - Outline of principles of UV/visible spectroscopy, fluorescence
techniques and applications to protein structure and enzyme assays.
? Protein Purification Techniques: Ultracentrifugation, chromatography,
electrophoresis as applied to the purification of proteins.
? Bioenergetics & Oxidative Phosphorylation: Free energy changes, reduction
potentials, coupled reactions and electron transport. Organisation of the inner
mitochondrial membrane and its relationship to the chemiosmotic theory.
? Carbohydrate Metabolism: Integration and regulation of glycolysis/
gluconeogenesis, glycogen metabolism, pentose phosphate pathway and the citric
? Amino Acid Metabolism: Integration and regulation of amino acid metabolism.
? Lipid & Cholesterol Metabolism: Integration and regulation of ?-oxidation, ketone
body metabolism, fatty acid synthesis, triglyceride metabolism and cholesterol
synthesis. Classification and roles of serum lipoproteins.
Teaching: Lectures, tutorials, workshops and practical sessions
STUDY OPTION 1:
? 3 hour Exam (50%)
? Coursework: Portfolio of laboratory reports (40%) and data interpretation
STUDY OPTION 2 OR 3:
? Practical report (50%)
? Continuous assessment portfolio (50%)
Study Option 1 = Whole Year
Study Option 2 = Autumn
Study Option 3 = Spring/summer
Courses and course hours of instruction are subject to change.
Eligibility for courses may be subject to a placement exam and/or pre-requisites.
Some courses may require additional fees.
Credits earned vary according to the policies of the students' home institutions. According to ISA policy and possible visa requirements, students must maintain full-time enrollment status, as determined by their home institutions, for the duration of the program.
Please reference fall and spring course lists as not all courses are taught during both semesters.
Please note that some courses with locals have recommended prerequisite courses. It is the student's responsibility to consult any recommended prerequisites prior to enrolling in their course.