Proteins and Metabolism

Kingston University

Course Description

  • Course Name

    Proteins and Metabolism

  • Host University

    Kingston University

  • Location

    London, England

  • Area of Study

    Botany, Life Sciences, Molecular Biology

  • Language Level

    Taught In English

  • Prerequisites

    Successful completion of introductory university-level module such as LS4002 or similar

  • Course Level Recommendations

    Upper

    ISA offers course level recommendations in an effort to facilitate the determination of course levels by credential evaluators.We advice each institution to have their own credentials evaluator make the final decision regrading course levels.

    Hours & Credits

  • Credits

    4
  • Recommended U.S. Semester Credits
    4
  • Recommended U.S. Quarter Units
    0
  • Overview

    Course Content:

    The module provides students with knowledge of the structure and methods of analysis of
    proteins, with particular emphasis on enzymes. This is followed by the study of the major
    catabolic and anabolic pathways and investigates how organisms obtain and use energy.

    These processes, and their regulation in health and disease, are considered at the
    molecular level, which involves many proteins including enzymes.

    Autumn Semester sumamry: the structure and methods of analysis of proteins, with
    particular emphasis on enzymes. Brief introduction of Bioenergetics.

    Spring Semester summary: the study of the major catabolic and anabolic pathways and
    how organisms obtain and use energy. Regulation of these in health and disease, are
    considered at the molecular level, which involves many proteins including enzymes.

    Topics covered may include:
    ? Amino Acids - Revision of basic structure and chemical properties. Structure of
    side chains.
    ? Protein Structure - Structure and properties of the peptide bond, levels of
    protein structure relating to primary structure and function of proteins.
    ? Enzymes - Structural features of enzymes relating to function. Measurement of
    enzyme activity, including calculation of kinetic parameters and enzyme
    inhibition.
    ? Spectroscopy - Outline of principles of UV/visible spectroscopy, fluorescence
    techniques and applications to protein structure and enzyme assays.
    ? Protein Purification Techniques: Ultracentrifugation, chromatography,
    electrophoresis as applied to the purification of proteins.
    ? Bioenergetics & Oxidative Phosphorylation: Free energy changes, reduction
    potentials, coupled reactions and electron transport. Organisation of the inner
    mitochondrial membrane and its relationship to the chemiosmotic theory.
    ? Carbohydrate Metabolism: Integration and regulation of glycolysis/
    gluconeogenesis, glycogen metabolism, pentose phosphate pathway and the citric
    acid cycle.
    ? Amino Acid Metabolism: Integration and regulation of amino acid metabolism.
    ? Lipid & Cholesterol Metabolism: Integration and regulation of ?-oxidation, ketone
    body metabolism, fatty acid synthesis, triglyceride metabolism and cholesterol
    synthesis. Classification and roles of serum lipoproteins.

    Teaching: Lectures, tutorials, workshops and practical sessions

    Assessment:
    STUDY OPTION 1:
    ? 3 hour Exam (50%)
    ? Coursework: Portfolio of laboratory reports (40%) and data interpretation
    exercise (10%)
    STUDY OPTION 2 OR 3:
    ? Practical report (50%)
    ? Continuous assessment portfolio (50%)

    Study Option 1 = Whole Year
    Study Option 2 = Autumn
    Study Option 3 = Spring/summer

Course Disclaimer

Courses and course hours of instruction are subject to change.

Eligibility for courses may be subject to a placement exam and/or pre-requisites.

Some courses may require additional fees.

Credits earned vary according to the policies of the students' home institutions. According to ISA policy and possible visa requirements, students must maintain full-time enrollment status, as determined by their home institutions, for the duration of the program.

Please reference fall and spring course lists as not all courses are taught during both semesters.

Please note that some courses with locals have recommended prerequisite courses. It is the student's responsibility to consult any recommended prerequisites prior to enrolling in their course.