Protein Structure & Function

King's College London

Course Description

  • Course Name

    Protein Structure & Function

  • Host University

    King's College London

  • Location

    London, England

  • Area of Study

    Biochemistry

  • Language Level

    Taught In English

  • Prerequisites

    4BBY1020 Chemistry for the Biosciences

  • Course Level Recommendations

    Upper

    ISA offers course level recommendations in an effort to facilitate the determination of course levels by credential evaluators.We advice each institution to have their own credentials evaluator make the final decision regrading course levels.

    Hours & Credits

  • UK Credits

    15
  • Recommended U.S. Semester Credits
    4
  • Recommended U.S. Quarter Units
    6
  • Overview

    Educational Aims: To provide an account of structure-function relationships in proteins. To understand the molecular bases of biological function of proteins.
    Fundamental aspects of structural biology and protein chemistry will be explained, with an emphasis on the relationship to biological function. Students are expected to have already a good understanding of biochemistry and chemistry and a basic understanding of protein structure (covered in first-year Chemistry and Biochemistry).

    Learning Outcomes:
    By the end of the course the student will:
    -Be familiar with the basic principles and theories of protein structure
    -Be aware of the variety of structural motifs in proteins and general classification of protein structure
    -Understand the basic structure/activity paradigms in proteins including co-operation and all ostery in enzymes and the importance of protein-protein interactions
    -Be aware of various theories of protein folding and the prediction of higher orders of structure from sequence data
    -Be conversant with the structure-mechanism relations of selected classes of proteins/systems (including selected enzymes, membrane proteins, ribosomes,chaperones, DNA binding proteins, muscle proteins)
    -Be able to manipulate protein structures using molecular graphics computer software
    -Be able to analyse and interpret data on protein structure, molecular interactions and enzyme catalysis

    Students should also be able to
    -Work quantitatively with biochemical, biophysical and structural biology data
    -Interpret data from experimental investigations on protein structure and function

    Suggested Reading: There is no single recommended textbook for this course, but there are multiple copies of several suitable texts in the library. Recommended textbooks for general principles include: M. Williamson, "How Proteins Work", Garland Science Voet & Voet, "Biochemistry" 4th Edition, Wiley Kuriyan, Konforti & Wemmer, "The Molecules of Life", Garland Science C. Branden & J. Tooze, "Introduction to Protein Structure" 2nd Edition, Garland Publishing (ISBN 0-8153-2305-0) Additional reference materials will be suggested for individual lectures. A good source for many aspects of protein structure and function is the journal series "Trends in Biochemical Sciences" and "Current Opinion in Structural Biology".

Course Disclaimer

Courses and course hours of instruction are subject to change.

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Please reference fall and spring course lists as not all courses are taught during both semesters.

Please note that some courses with locals have recommended prerequisite courses. It is the student's responsibility to consult any recommended prerequisites prior to enrolling in their course.