Vrije Universiteit Amsterdam
Amsterdam, The Netherlands
Area of Study
Taught In English
Course Level Recommendations
ISA offers course level recommendations in an effort to facilitate the determination of course levels by credential evaluators.We advice each institution to have their own credentials evaluator make the final decision regrading course levels.
Recommended U.S. Semester Credits3
Recommended U.S. Quarter Units4
Hours & Credits
Learning objectives, subdivided over the main topics of the course :
• Molecular Genetics; the student can:
- describe the composition and molecular structure of the human genome
- describe how genes look like and apply this knowledge in explaining genetic abnormalities
- indicate the differences between a bacterial and eukaryotic genome
- describe the process of transcription, RNA processing and translation
- indicate the relationship between regulation of gene expression, cell differentiation and embryonic development
- describe mitosis and meiosis
- describe and recognize abnormalities in chromosome structure and number, and explain the consequences
• DNA replication, mutations and diseases; the student can:
- describe the different stages of the cell cycle
- describe the process of DNA replication in prokaryotes and eukaryotes
- explain how environmental factors and certain chemical compounds can damage DNA and cause mutations
- indicate the origin of mutations and describe DNA repair mechanisms
- define the different mutations at DNA and protein level and explain the consequences for the functioning of genes and proteins
• Inheritance patterns; the student
- can identify and understand Mendelian and inheritance patterns
- can identify and explain non-Mendelian inheritance patterns
- can calculate and predict the likelihood of inheriting a particular genetic trait for Mendelian and non-Mendelian modes of inheritance
• Experimental approaches: the student is able to:
- apply and explain experimental approaches that are used to study genomes and genes as well as gene expression and the encoded proteins
- explain the importance and application of model systems, such as yeast, Drosophila and mouse, to study genetics and the functions of genes
- apply mathematical skills in performing experiments and in analyzing result.
In this course, you will study the composition and structure of the human genome, how it is replicated and inherited. We will discuss how
the stored information in chromosomes is retrieved and used, and how genes are regulated at the molecular level to perform their function.
Important in this discussion is the genetic variation in the human population. Particularly the ‘mistakes’ that are found in genes and
cause diseases. You will discover how these mutations arise, what the consequences are, and how they can explain the various types of inheritance patterns.
You will practice and extend your knowledge via:
- Tutorials: making assignments and discuss them
- Laboratory practicals: become familiar with basic lab. skills and molecular genetic experiments
- Computer practicals: introduction into bioinformatics and the use of online databases which contain genetic and molecular information about human genes, proteins, mutations, and diseases.
• Lectures (36 hours)
• Tutorials and assignments (8 hours)
• Computer practicals and assignments (8 hours)
• Laboratory practicals (12 hours)
• Book assignments (12 hours)
TYPE OF ASSESSMENT
• Computer-based multiple choice Exam (85% of the final mark) consisting of two partial exams: Partial exam 1 (45%) in the fourth week and partial exam 2 (55%) in the eight week, each consisting of 75-80 multiple choice questions. The grade for the theoretical part of the course is the weighted average of the partial exam grades. A re-examination of a partial exam is not allowed. In case of a re-exam, the re-exam covers all topics of the course.
• Computer and Tutorial assignments (15% of the final mark)
• Book assignments; these should be made online via the Connect website of the book and must be sufficient (> 5.5)
• Laboratory practicals / experiments: Execution and accurate record keeping in Lab-Note book must be sufficient (>5.5)
Courses and course hours of instruction are subject to change.
Some courses may require additional fees.